XiTRON Technologies was an early developer in the field of Bioimpedance Spectroscopy (BIS) for estimating intracellular and extracellular water (ICW and ECW), total body water (TBW), fat mass (FM), and fat free mass (FFM) for body composition in healthy individuals. The acquisition of XiTRON Technologies by ImpediMed in 2007 adds the XiTRON Hydra 4200 to the ImpediMed product offering.

In 1990, XiTRON provided the body composition research community with a bioimpedance device capable of measurements at numerous frequencies, and with a wide enough frequency range (5kHz-1MHz) to compute the standard Cole model of biological tissue. Soon after, XiTRON provided its customers with the software for computing the four-dimensional nonlinear Cole model. At the same time, XiTRON also provided its customers with software for computing ECW and ICW volume using equations XiTRON developed from Hanai’s mixture theory.

Today’s XiTRON Hydra 4200 is a 3rd generation, single-channel, tetra polar BIS device that scans 50 frequencies between 5kHz and 1MHz. Its use has been reported numerous times in scientific journals. Scientific studies have also shown the technology to be repeatable and sensitive to small changes, able to detect the volume distribution differences between subjects.

Download the Hydra product brochure (PDF, 3.7MB)

For additional information on Hydra 4200 and other bioimpedance products from ImpediMed, Inc, please visit www.impedimed.com.

Clinical papers using XiTRON's Hydra 4200 device include:
Note: The Hydra 4200 is intended to be used on healthy individuals

  • Kraemer M, Rode C, Wizemann V. Detection limit of methods to assess fluid status
    changes in dialysis patients. Kidney Int. 2006 Feb 22; [Epub ahead of print]

  • De Lorenzo A, Andreoli A, Matthie J, Withers P. Predicting body cell mass with bioimpedance by using theoretical methods: a technological review. J Appl Physiol. 1997 May;82(5):1542-58. Review. Erratum in: J Appl Physiol 1997 Dec;83(6):followi.

  • Ellis KJ, Shypailo RJ, Wong WW. Measurement of body water by multifrequency bioelectrical impedance spectroscopy in a multiethnic pediatric population. Am J Clin Nutr. 1999 Nov;70(5):847-53. Erratum in: Am J Clin Nutr 2000 Jun;71(6):1618.

  • Earthman CP, Matthie JR, Reid PM, Harper IT, Ravussin E, Howell WH. A comparison of bioimpedance methods for detection of body cell mass change in HIV infection.
    J Appl Physiol. 2000 Mar;88(3):944-56.

  • Matthie JR. Second generation mixture theory equation for estimating intracellular water using bioimpedance spectroscopy. J Appl Physiol. 2005 Aug;99(2):780-1.